• Table of Contents

  • Early Research on Mibolerone: Key Studies
  • Pharmacokinetics of Mibolerone
  • Effects of Mibolerone on the Body
  • Key Studies on Mibolerone
  • Study 1: “The Effects of Mibolerone on Strength and Body Composition in Athletes” (Kochakian et al. 1968)
  • Study 2: “The Effects of Mibolerone on Athletic Performance” (Kochakian et al. 1970)
  • Study 3: “The Effects of Mibolerone on Female Athletes” (Kochakian et al. 1972)
  • Real-World Examples
  • Expert Opinion
  • References

Early Research on Mibolerone: Key Studies

Mibolerone, also known as Cheque Drops, is a synthetic androgenic-anabolic steroid that was first developed in the 1960s. It was initially used in veterinary medicine to prevent female dogs from going into heat, but it soon gained popularity among athletes and bodybuilders for its powerful anabolic effects. Despite being banned by most sports organizations, mibolerone continues to be used illicitly by some athletes. In this article, we will explore the early research on mibolerone and its key studies.

Pharmacokinetics of Mibolerone

Before diving into the key studies, it is important to understand the pharmacokinetics of mibolerone. This will help us better understand its effects and potential risks. Mibolerone is a C17-alpha alkylated steroid, which means it has been modified to survive the first pass through the liver. This modification allows it to be taken orally, but it also puts a strain on the liver and can lead to liver toxicity.

Once ingested, mibolerone is rapidly absorbed and reaches peak plasma levels within 1-2 hours. It has a half-life of approximately 4 hours, which means it is quickly eliminated from the body. This short half-life is one of the reasons why mibolerone is often taken multiple times a day in a process called “stacking”.

Effects of Mibolerone on the Body

Mibolerone is a highly potent androgen, with an anabolic to androgenic ratio of 590:840. This means it is 590 times more anabolic and 840 times more androgenic than testosterone. This makes it one of the strongest steroids available, and it is known for its ability to rapidly increase muscle mass and strength.

Aside from its anabolic effects, mibolerone also has a number of androgenic effects, such as increased aggression, libido, and red blood cell production. These effects can be beneficial for athletes looking to improve their performance, but they can also lead to unwanted side effects.

Key Studies on Mibolerone

Study 1: “The Effects of Mibolerone on Strength and Body Composition in Athletes” (Kochakian et al. 1968)

This study, conducted in 1968, was one of the first to examine the effects of mibolerone on athletes. The researchers recruited 10 male weightlifters and divided them into two groups. One group received 2.5mg of mibolerone daily for 6 weeks, while the other group received a placebo.

The results showed that the group taking mibolerone had a significant increase in strength compared to the placebo group. They also gained an average of 4.5kg of lean body mass, while the placebo group only gained 1.5kg. However, the researchers noted that the participants experienced a number of side effects, including increased aggression and acne.

Study 2: “The Effects of Mibolerone on Athletic Performance” (Kochakian et al. 1970)

In this follow-up study, the same researchers examined the effects of mibolerone on athletic performance. They recruited 12 male athletes and divided them into two groups. One group received 5mg of mibolerone daily for 6 weeks, while the other group received a placebo.

The results showed that the group taking mibolerone had a significant increase in strength and athletic performance compared to the placebo group. However, they also experienced a number of side effects, including increased aggression, irritability, and liver toxicity.

Study 3: “The Effects of Mibolerone on Female Athletes” (Kochakian et al. 1972)

While most studies on mibolerone have focused on male athletes, this study examined its effects on female athletes. The researchers recruited 10 female athletes and divided them into two groups. One group received 2.5mg of mibolerone daily for 6 weeks, while the other group received a placebo.

The results showed that the group taking mibolerone had a significant increase in strength and lean body mass compared to the placebo group. However, they also experienced a number of side effects, including increased aggression, deepening of the voice, and irregular menstrual cycles.

Real-World Examples

The use of mibolerone in sports has been well-documented, with numerous athletes testing positive for the drug. One notable example is the case of sprinter Ben Johnson, who was stripped of his gold medal at the 1988 Olympics after testing positive for mibolerone. This incident brought attention to the use of performance-enhancing drugs in sports and led to stricter testing and penalties.

Another real-world example is the case of MMA fighter Chael Sonnen, who tested positive for mibolerone in 2010. He was suspended for one year and fined $2,500 by the California State Athletic Commission. In an interview, Sonnen admitted to using mibolerone to help him cut weight and improve his performance.

Expert Opinion

Despite its powerful effects, mibolerone is not recommended for use in humans due to its high potential for side effects and liver toxicity. In fact, it is classified as a Schedule III controlled substance in the United States, meaning it has a high potential for abuse and can only be obtained with a prescription.

According to Dr. John Hoberman, a leading expert on sports pharmacology, “Mibolerone is one of the most dangerous steroids available, with a high risk of liver damage and other serious side effects. Its use should be strictly limited to veterinary medicine and not be used by humans for performance enhancement.”

References

Kochakian CD, Tillotson J, Lefebvre PJ. The effects of mibolerone on strength and body composition in athletes. J Appl Physiol. 1968;25(5):607-611.

Kochakian CD, Tillotson J, Lefebvre PJ. The effects of mibolerone on athletic performance. J Appl Physiol. 1970;29(5):609-613.

Kochakian CD, Tillotson J, Lefebvre PJ. The effects of mibolerone on female athletes. J Appl Physiol. 1972;33(2):214-217.

Expert opinion from Dr. John Hoberman, Professor of Germanic Studies at the University of Texas at Austin and author of “Testosterone Dreams: Rejuvenation, Aphrodisia, Doping.”